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Advocates with this treatment approach, referred to as Sinclair method, claim you'd likely experience no withdrawal symptoms. According to proponents, after three or four months on the medication, all while still being in a position to continue to drink, you'd experience diminished cravings as well as find that your urge to drink disappears. Using two separate drugs to lose weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you should err assisting caution and let the FDA do its job and demand some investigation be done so the public is aware of the side effects and dangers of the medications before we take them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on his or her medications. Researchers found out that participants taking this drug for any year, lost weight within 4 weeks and have kept the extra weight off throughout the 56 weeks of the study. Contrave is a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which are made up of many active ingredient, which might make them more potent and safer. Combo-pilling may be the newest fad or in addition to this the newest in the future under scrutiny and so it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular could be the fact that since right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug can also raise blood pressure level and heart rate, and shouldn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must stop used in patients with uncontrolled high blood pressure, and also by a person with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. Other people who must avoid using Contrave are patients experiencing bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave shouldn't be prescribed for females who are pregnant or attempting to become pregnant.