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The drugs, acamprosate (marketing name: Campral) and naltrexone (ReVia) were found to help those struggling in numerous phases of recovery. Acamprosate helped manage emotional triggers in those who had already stopped drinking, naltrexone helped manage cravings in heavy drinkers who are looking to stop drinking or recently quit. Using two separate drugs to lose weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people who go through it you ought to err along the side of caution and permit the FDA do its job and demand some study be done in order that the public knows the side effects and hazards of the medications before we bring them. Keep in mind that drug companies come in business to generate income and that they would say almost anything to keep people on the medications. Researchers found out that participants investing in this drug to get a year, lost excess weight within 4 weeks and have kept the body weight off throughout the 56 weeks with the study. Contrave is a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more efficient and safer. Combo-pilling is the newest fad or in addition to this the newest to come under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular will be the fact that at the time of right now there are no long term prescription weight loss supplements that have been authorized by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug may also raise blood pressure and pulse rate, and shouldn't be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must 't be used in patients with uncontrolled high blood pressure levels, and also by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation. Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant if the addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed within the liver right after uptake from the intestines and possesses no therapeutic effect. Buprenorphine will be the active substance; it's absorbed underneath the tongue (and throughout the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I purchased this formulation in the event the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who may have had gastric bypass, in which the first area of the intestine is bypassed and also the stomach contents empty into a more distal part of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy the location where the drug is taken up from the duodenum and transferred straight to the liver with the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be taken up by areas of the intestine which are not served through the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.