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This part of the problem regulates reward responses in establishing food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both after they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed pounds can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you need to err assisting caution and let the FDA do its job and demand some study be done so the public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on his or her medications. Researchers discovered that participants taking this drug for the year, lost excess weight within 4 weeks and have kept the weight off through the entire 56 weeks with the study. Contrave is a combination with the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which can be made up of multiple active ingredient, that might make them far better and safer. Combo-pilling will be the newest fad or even better the newest into the future under scrutiny and so it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that by right now there aren't any long term prescription weightloss pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise hypertension and heartrate, and shouldn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must 't be used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking. The most common unwanted effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.